Key result
Fisetin attenuated doxorubicin-induced cardiomyopathy in rat and cell models by inhibiting ferroptosis via activation of the SIRT1/Nrf2 signaling pathway.
Why the study?
Fisetin has been reported to exert cardioprotective effects against doxorubicin-induced cardiotoxicity in experimental rats, but the underlying mechanisms remain unknown.
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May support SIRT1/Nrf2 targeting in doxorubicin cardiotoxicity models; leaves open clinical translation.
Li et al. (2022) studied Doxorubicin-induced cardiomyopathy. Fisetin vs. Control/Doxorubicin alone was evaluated on Cardiotoxicity, cardiac dysfunction, and ferroptosis. Fisetin attenuated doxorubicin-induced cardiomyopathy in rat and cell models by inhibiting ferroptosis via activation of the SIRT1/Nrf2 signaling pathway.
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