Non-aspirin NSAIDs are associated with serious cardiovascular side effects, including hypertension, heart failure, myocardial infarction, and stroke, leading to a general black box warning.
What are the cardiovascular risks and underlying mechanisms associated with non-aspirin NSAIDs?
This review highlights the serious cardiovascular risks of non-aspirin NSAIDs, including heart failure and ischemic events, reinforcing the rationale for their black box warning.
While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.
Meek et al. (Wed,) conducted a review in Cardiovascular risks associated with NSAIDs. Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) was evaluated. Non-aspirin NSAIDs are associated with serious cardiovascular side effects, including hypertension, heart failure, myocardial infarction, and stroke, leading to a general black box warning.