Key result
Comparative genome analysis of EV-A isolates in Madagascar revealed frequent genetic exchanges and a high degree of permissiveness for intertypic recombination among different EV-A types.
Why the study?
Human enteroviruses of species A cause hand-foot-and-mouth disease and severe neurological manifestations, prompting investigation into their circulation and molecular evolution in Madagascar.
Population
Eight different types of EV-A isolates collected mostly in 2011 in Madagascar
Design
Comparative genome analysis and recombinant engineering study
Authors
Loading...
Documents EV-A diversity in Madagascar; supports regional surveillance but leaves open genogroup F clinical impact.
Observational
The study demonstrates high genetic diversity and frequent recombination among enterovirus A strains in Madagascar, highlighting the need for surveillance to prevent potential hand-foot-and-mouth disease outbreaks.
Volle et al. (2019) conducted an observational in Human enteroviruses of species A (EV-A) infection. Genetic exchanges and intertypic recombination was evaluated on Circulation, diversity, and molecular evolution of EV-A. Comparative genome analysis of EV-A isolates in Madagascar revealed frequent genetic exchanges and a high degree of permissiveness for intertypic recombination among different EV-A types.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: