Key result
HIIT increases VO2max by ~8 mL/kg/min vs. non-exercise control in inactive adults.
Why the study?
Evidence on the effects of high-intensity interval training in physically inactive individuals, including those with extremely sedentary behavior, remains inconsistent.
Does high-intensity interval training improve body composition and cardiometabolic health in physically inactive individuals?
Systematic Review and Meta-Analysis (n=877)
Does high-intensity interval training improve body composition and cardiometabolic health in physically inactive individuals?
High-intensity interval training is a time-efficient exercise modality that improves cardiorespiratory fitness and selected cardiometabolic risk factors in physically inactive individuals, though current evidence is of low certainty.
Answers are grounded in this paper and cite their sources.
Supports HIIT for fitness gains in inactive adults; extends inconsistent prior evidence via pooled RCT data.
Background/Objectives: Increasing physical activity is important for reducing cardiometabolic risk. However, evidence on the effects of high-intensity interval training (HIIT) in physically inactive individuals, including those with extremely sedentary behavior, remains inconsistent. We evaluated the effects of HIIT on body composition and cardiometabolic outcomes compared with a non-exercise control (CON) and moderate-intensity continuous training (MICT). Methods: PubMed, Web of Science, Embase, the Cochrane Library, Ovid-hosted resources, and ClinicalTrials.gov were searched through 8 July 2026. The protocol was registered (PROSPERO CRD420251230848). Random-effects models were used. Risk of bias, evidence certainty, and robustness were assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, Grading of Recommendations Assessment, Development and Evaluation (GRADE), and leave-one-out analyses, respectively. Results: Twenty-four randomized trials involving 877 participants were analyzed. A conservative study-level summary classified all studies as having at least some concerns, including five at high risk of bias. Compared with CON, HIIT reduced body weight (weighted mean difference [WMD] = −1.60 kg), systolic blood pressure (WMD = −2.85 mmHg), diastolic blood pressure (WMD = −6.57 mmHg), low-density lipoprotein cholesterol (WMD = −0.29 mmol/L), and total cholesterol (WMD = −0.42 mmol/L), and increased maximal oxygen uptake (VO2max; WMD = 7.72 mL/kg/min). Compared with MICT, most outcomes showed no statistically significant differences, but HIIT produced a greater VO2max increase (WMD = 3.72 mL/kg/min). Several findings were sensitive to individual-study removal, and certainty of evidence was low or very low. No serious adverse events were reported in 11 studies; attendance or adherence was generally high in 15 studies, despite incomplete reporting and supervised interventions. Conclusions: HIIT may improve selected body composition and cardiometabolic outcomes, with VO2max showing a relatively consistent direction of effect. However, the certainty of evidence for most outcomes was low or very low; therefore, these findings should be interpreted with caution. Current evidence is insufficient to establish equivalence to MICT or identify an optimal HIIT protocol. Larger, longer-term, high-quality trials using objective measures of sedentary behavior are needed, particularly in extremely sedentary populations.
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Lan et al. (2026) conducted a systematic review and meta-analysis in Physical inactivity (n=877). High-intensity interval training (HIIT) vs. Non-exercise control (CON) or moderate-intensity continuous training (MICT) was evaluated on Maximal oxygen uptake (VO2max) (WMD 7.72 mL/kg/min, 95% CI 3.69 to 11.74, p=0.0002). High-intensity interval training significantly increased maximal oxygen uptake (WMD 7.72 mL/kg/min) compared to non-exercise control in physically inactive individuals.
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