Key result
This review summarizes evidence on the associations of genetic variants with platelet phenotypes and their clinical ramifications for personalizing antiplatelet therapies.
This review summarizes the genetic regulation of platelet function and its implications for personalizing antiplatelet pharmacotherapy.
Clause 1 (clinical): Remains hypothesis-generating for personalizing antiplate.
Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.
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Williams et al. (2010) conducted a review in Platelet function and antiplatelet therapy. Genetic variants was evaluated. This review summarizes evidence on the associations of genetic variants with platelet phenotypes and their clinical ramifications for personalizing antiplatelet therapies.
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