Key result
Human platelet alloantigen (HPA)-1b and HPA-5b polymorphisms were significantly associated with ischemic stroke, with higher frequencies of HPA-1 a/b and HPA-5 a/b alleles in patients (p<0.001).
Why the study?
Are human platelet alloantigen (HPA) 1 through 5 polymorphisms associated with ischemic stroke?
Case-Control (n=534)
Are human platelet alloantigen (HPA) 1 through 5 polymorphisms associated with ischemic stroke?
p-value: p=<0.001
HPA-1b and HPA-5b polymorphisms represent strong genetic risk factors for ischemic stroke.
HPA-1/5 variants were associated with stroke; hypothesis-generating for genetic risk stratification, prospective validation needed.
Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were investigated in 216 stroke patients and 318 matched control subjects. HPA genotyping was done by the polymerase chain reaction method using sequence-specific primers. Higher frequencies of the HPA-1 a/b (p < 0.001) and HPA-5 a/b (p < 0.001) allele, together with HPA-1 b/b, HPA-5 a/b and HPA-5 b/b genotypes were seen in patients, which was confirmed by regression analysis after controlling for a number of confounding variables. Furthermore, HPA-1 b/b and HPA-5 b/b were significantly associated with the extent of neurological symptoms, and with the recurrence of stroke. Both susceptible (1a/ b -2a/a-3a/ b -4a/a-5a/ b ) and protective (1a/a-2a/a-3a/a-4a/a-5a/a; 1a/a-2a/a-3a/ b -4a/a-5a/a; 1a/ b -2a/a-3a/a-4a/a-5a/a; 1a/ b -2a/a-3a/ b -4a/a-5a/a) HPA genotypes were identified. This is the first evidence demonstrating differential association of the common 5 HPA gene variants with stroke, with HPA-1b and HPA-5b representing strong genetic risk factors.
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Saidi et al. (2007) conducted a case-control in Ischemic Stroke (n=534). Human Platelet Alloantigen (HPA) 1 through 5 Polymorphisms vs. Matched control subjects was evaluated on Ischemic stroke (p=<0.001). Human platelet alloantigen (HPA)-1b and HPA-5b polymorphisms were significantly associated with ischemic stroke, with higher frequencies of HPA-1 a/b and HPA-5 a/b alleles in patients (p<0.001).
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