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This research aims to investigate CTGF's role in kidney inflammation through the NF-κB signaling pathway.

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF-κB

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This research aims to investigate CTGF's role in kidney inflammation through the NF-κB signaling pathway.
Systemic administration of CTGF to mice for 24 hours
Evaluation of renal inflammatory cell infiltration
Use of NF-kappaB inhibitor, parthenolide, to assess its effect on inflammation
CTGF administration to mice led to significant inflammatory cell infiltration in the renal interstitium (p<0.05)
Elevated renal NF-kappaB activity was observed after CTGF treatment
Parthenolide treatment significantly reduced CTGF-induced proinflammatory cytokine and chemokine expression.

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Randomized trial demonstrates CTGF's role in inflammatory cell infiltration in kidney, suggesting a target for therapy.

Sánchez‐López et al. (2009) studied this question.

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