Prospective Associations of Accelerometer-Measured Physical Activity and Sedentary Time With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality

mortality neoplasms public health sedentary behavior B oth insufficient moderate-to-vigorous intensity physical activity (MVPA) and high volumes of sedentary time (ST) have been associated with increased risk of all-cause mortality, cardiovascular disease (CVD), and some cancers. 1 However, epidemiological evidence has relied mostly on self-reported physical activity (PA) and ST measures, which are prone to reporting bias and measurement error. Cohort studies incorporating more objective assessments are emerging, 2-4 but few investigate relationships of accelerometer-measured PA and ST with clinical end points, particularly incident CVD, and include both men and women. 5 In addition, the relevance of light intensity PA (LIPA) in this context, which is an important contributor to total PA and may be a more feasible behavioral target for middle to older aged adults, remains unclear. Here, we examine the prospective associations of accelerometer-measured PA and ST with incident CVD (primary outcome), incident cancer, and all-cause mortality.