Accelerometer-Measured Physical Activity and Sedentary Behavior in Relation to All-Cause Mortality
Key result
Higher accelerometer-measured physical activity linked to lower all-cause mortality in women.
- n=16,741
Why the study?
Current physical activity guidelines are based primarily on self-reported data, and well-designed studies using device-based assessments of light-intensity physical activity and sedentary behavior with clinical outcomes are needed to update guidelines.
Does accelerometer-measured physical activity and sedentary behavior associate with all-cause mortality in women?
Population
16,741 women from the Women's Health Study with compliant accelerometer wear data
Comparison
Levels of accelerometer-measured physical activity and sedentary behavior
Design
Prospective cohort study
Follow-up
Through December 31, 2015
Authors
Discussion
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Member takes
Key expert perspectives
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
ILI-Min LeeProfessor of medicine and epidemiology, Harvard University
“What is new and important is how strong this association is when we have more precise measures of physical activity – the most active women had a 60-70% reduction in mortality rates, compared with the least active, during the study. For context, non-smokers have about a 50% risk reduction, compared to smokers, which is why patients (and doctors) should pay attention to being physically active.”
ILI-Min LeeProfessor of medicine and epidemiology, Harvard University
“We used devices to better measure not only higher intensity physical activities, but also lower intensity activities and sedentary behavior, which has become of great interest in the last few years.”
Implication
Prospective cohort study reveals higher device-measured physical activity reduces all-cause mortality across populations, highlighting the critical health risks associated with prolonged sitting.
Key Points
- Evaluate the associations between device-measured physical activity of varying intensities, sedentary time, and all-cause mortality risk.
- Quantified daily sedentary duration, light activity, and moderate-to-vigorous physical activity using wearable accelerometers.
- Tracked prospective all-cause mortality over follow-up utilizing multivariable Cox proportional hazards regression models adjusted for potential confounders.
- Higher volumes of total physical activity and moderate-to-vigorous activity show substantial, dose-dependent reductions in all-cause mortality risk.
- High levels of sedentary behavior correlate with elevated mortality risk, especially among individuals accumulating minimal daily physical activity.
Study Design
Type
Cohort (n=16,741)
Structured PICO
Does accelerometer-measured physical activity and sedentary behavior associate with all-cause mortality in women?
P
Population
16,741 women capable of walking unassisted outside the home, followed through December 2015 for mortality.
E
Exposure
Accelerometer-measured physical activity and sedentary behavior (ActiGraph GT3X+ worn on the hip for 7 days).
O
Outcome
All-cause mortality confirmed with medical records, death certificates, or the National Death Index through December 31, 2015.hard clinical
Cite This Study
Lee et al. (2017) reported a cohort. Accelerometer-measured physical activity and sedentary behavior was evaluated on Mortality. The study examined the association of accelerometer-measured physical activity and sedentary behavior with all-cause mortality in 16,741 women, though results are truncated in the abstract.