Key result
This review provides an overview of platelet biology and its primary functions to serve as a foundation for understanding the pathophysiology and treatment of platelet disorders.
This review provides a foundational overview of platelet biology and functions to aid in understanding the pathophysiology and treatment of platelet disorders.
Supports clinician education on platelet disorders; leaves open prospective trials integrating new biologic insights into practice.
SUMMARY Understanding the biology of platelet is important for one to treat patients with acquired or inherited platelet disorders. Platelets provide primary hemostasis by performing five primary functions: adhesion, aggregation, secretion, and providing procoagulant surface and clot retraction. The elucidation of the molecular mechanisms carrying out these functions has led to a better understanding of the pathophysiology of bleeding and the development of new approaches in treating patients with qualitative and quantitative platelet disorders. The purpose of this review is to provide a foundation for understanding the other papers in this publication on the treatment of platelet disorders.
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Thomas S. Kickler (2006) conducted a review in Platelet disorders. This review provides an overview of platelet biology and its primary functions to serve as a foundation for understanding the pathophysiology and treatment of platelet disorders.
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