Key result
This review summarizes the current understanding of platelet biology, highlighting the critical role of hemodynamics and introducing the emerging concept of shear microgradients in platelet function.
This review summarizes the current understanding of platelet biology, emphasizing the critical role of hemodynamics and introducing the emerging concept of shear microgradients.
This is the authors' abstract. We don't add key points for this paper.
Platelets are anucleated fragments produced by megakaryocytes that circulate in the blood. Platelets are involved in the initial cellular response to damaged endothelium and migrate to this area to prevent excessive bleeding. What is becoming more acknowledged over the last few decades is that blood flow (hemodynamics) plays a critical role in platelet function. The purpose of this review is to summarize the current understanding of platelet biology with particular focus on the role of hemodynamics. The emerging concept of shear microgradients, which are challenging the traditional model of platelet function, will also be introduced in the review.
Supports expanded research into hemodynamic platelet influences; leaves open clinical translation pending prospective data.
No takes yet. Share an insight, caveat, or question.
Angus Wong (2013) conducted a review in Platelet biology and hemodynamics. Hemodynamics (shear microgradients) was evaluated. This review summarizes the current understanding of platelet biology, highlighting the critical role of hemodynamics and introducing the emerging concept of shear microgradients in platelet function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: