Key result
Endothelin-1 and Sarafotoxin S6b stimulated aldosterone secretion in cultured calf zona glomerulosa cells and demonstrated specific high-affinity receptor binding.
Population
Cultured calf zona glomerulosa cells
Design
Preclinical
Authors
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ET-1 stimulates aldosterone in adrenal cells; leaves open its role in human hypertension.
Endothelins and Sarafotoxin S6b stimulate aldosterone secretion in cultured calf zona glomerulosa cells through specific high-affinity receptors.
Gómez-Sánchez et al. (1990) studied this question. Endothelins (ET-1, ET-2, ET-3) and Sarafotoxin S6b was evaluated on Receptor binding characteristics and aldosterone secretion. Endothelin-1 and Sarafotoxin S6b stimulated aldosterone secretion in cultured calf zona glomerulosa cells and demonstrated specific high-affinity receptor binding.
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