Key result
Dual-crosslinking hydrogel injection improved ejection fraction by 37% relative to myocardial infarction control at 8 weeks (P=0.014) in an ovine model.
Why the study?
Does injection of dual-crosslinking hyaluronic acid hydrogels improve ejection fraction and limit left ventricular remodeling in an ovine model of myocardial infarction?
Population
Ovine model with posterolateral myocardial infarcts (n≥6 per group)
Comparison
Injection of hyaluronic acid hydrogels using a… vs Injection of saline
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports hydrogel development for post-MI remodeling in large animals; leaves open clinical translation.
Does injection of dual-crosslinking hyaluronic acid hydrogels improve ejection fraction and limit left ventricular remodeling in an ovine model of myocardial infarction?
p-value: p=0.014
A percutaneously deliverable, dual-crosslinking hyaluronic acid hydrogel significantly improved ejection fraction and mitigated left ventricular remodeling in an ovine myocardial infarction model.
Rodell et al. (2016) studied Myocardial infarction. Dual-crosslinking hyaluronic acid hydrogel vs. Saline (myocardial infarction control) and guest-host hydrogels was evaluated on Ejection fraction improvement relative to myocardial infarction control at 8 weeks (p=0.014). Dual-crosslinking hydrogel injection improved ejection fraction by 37% relative to myocardial infarction control at 8 weeks (P=0.014) in an ovine model.
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