Key result
Anteroapical infarction in sheep extends fully perfused hypocontractile borderzone into normal myocardium during remodeling.
Why the study?
The contribution and progression of perfused, hypocontractile borderzone myocardium adjacent to expanding infarcts during postinfarction remodeling is unknown.
Population
Eight sheep with anteroapical myocardial infarction
Comparison
Borderzone myocardium before and after infarction over time
Design
Experimental animal study using sonomicrometry and microsphere injections
Follow-up
Eight weeks
Authors
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Cardiovascular analysis reveals expansion of borderzone myocardium in postinfarction dilated cardiomyopathy, suggesting progressive structural remodeling beyond the initial infarct zone.
Jackson et al. (2002) studied Anteroapical myocardial infarction (n=8). Anteroapical infarction vs. Baseline (before infarction) was evaluated on Changes in regional myocardial contractility, geometry, and perfusion. Anteroapical infarction in a sheep model led to the progressive extension of fully perfused, hypocontractile borderzone myocardium into contiguous normal myocardium during remodeling.
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