Key result
A computational model of an idealized left ventricle demonstrated that the ischemic border zone expands over time and can be categorized into three distinct regions of impaired electrical conductivity.
Why the study?
The role of the border zone in initiating LV remodeling prompted investigation into the correlation between early border zone changes and remodeling outcomes during MI onset.
An electro-chemical coupled computational model demonstrates that the ischemic border zone expands over time and can be categorized into three conductivity-based sub-regions, potentially serving as a biomarker for myocardial injury reversibility.
Myocardial infarction (MI) is the most common cause of a heart failure, which occurs due to myocardial ischemia leading to left ventricular (LV) remodeling. LV remodeling particularly occurs at the ischemic area and the region surrounds it, known as the border zone. The role of the border zone in initiating LV remodeling process urges the investigation on the correlation between early border zone changes and remodeling outcome. Thus, this study aims to simulate a preliminary conceptual work of the border zone formation and evolution during onset of MI and its effect towards early LV remodeling processes by incorporating the oxygen concentration effect on the electrophysiology of an idealized three-dimensional LV through electro-chemical coupled mathematical model. The simulation result shows that the region of border zone, represented by the distribution of electrical conductivities, keeps expanding over time. Based on this result, the border zone is also proposed to consist of three sub-regions, namely mildly, moderately, and seriously impaired conductivity regions, which each region categorized depending on its electrical conductivities. This division could be used as a biomarker for classification of reversible and irreversible myocardial injury and will help to identify the different risks for the survival of patient. Larger ischemic size and complete occlusion of the coronary artery can be associated with an increased risk of developing irreversible injury, in particular if the reperfusion treatment is delayed. Increased irreversible injury area can be related with cardiovascular events and will further deteriorate the LV function over time.
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Naim et al. (2020) studied Myocardial infarction. Electro-chemical coupled computational model was evaluated on Border zone formation and evolution. A computational model of an idealized left ventricle demonstrated that the ischemic border zone expands over time and can be categorized into three distinct regions of impaired electrical conductivity.
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