February 20, 2001Circulation
Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women
Key result
High IL-6 levels were associated with a greater than 4-fold increased risk of death among older women with prevalent cardiovascular disease (RR 4.6; 95% CI 2.0 to 10.5).
Why the study?
Does high interleukin-6 (IL-6) level predict all-cause mortality in disabled older women with and without cardiovascular disease?
Population
620 disabled women ≥65 years old
Comparison
High interleukin-6 serum level vs Lowest interleukin-6 serum level
Design
Cohort
Follow-up
3 years
Authors
Discussion
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Member takes
Implication
High IL-6 may stratify mortality risk among disabled older women with CVD; leaves open whether inflammation is causal or modifiable.
Study Design
Type
Cohort (n=620)
Structured PICO
Does high interleukin-6 (IL-6) level predict all-cause mortality in disabled older women with and without cardiovascular disease?
P
Population
620 disabled women aged ≥65 years, followed for 3 years to assess the association between IL-6 levels, cardiovascular disease, and mortality.
E
Exposure
High interleukin-6 (IL-6) serum level (highest tertile)
C
Comparator
Lowest interleukin-6 (IL-6) serum level (lowest tertile)
O
Outcome
All-cause mortality over 3 yearshard clinical
Main Result
Relative Risk: 4.6 (95% CI 2–10.5)
High IL-6 levels strongly predict 3-year all-cause mortality in older disabled women with prevalent cardiovascular disease, suggesting systemic inflammation is a key prognostic marker in this population.
Cite This Study
Volpato et al. (2001) conducted a cohort in Cardiovascular disease (n=620). High interleukin-6 (IL-6) level (highest tertile) vs. Lowest IL-6 tertile was evaluated on All-cause mortality (RR 4.6, 95% CI 2.0 to 10.5). High IL-6 levels were associated with a greater than 4-fold increased risk of death among older women with prevalent cardiovascular disease (RR 4.6; 95% CI 2.0 to 10.5).