Injection of mRNAs derived from cloned cDNAs of NGK1 and NGK2 into Xenopus oocytes directed the formation of functional potassium channels with properties of delayed rectifiers.
Cloning of NGK1 and NGK2 from neuroblastoma-glioma cells reveals they form functional delayed rectifier potassium channels.
The complete amino acid sequences of two potassium channel proteins from NG108-15 neuroblastoma-glioma hybrid cells have been deduced by cloning and sequencing the cDNAs. One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product. mRNAs derived from both the cloned cDNAs, when injected into Xenopus oocytes, direct the formation of functional potassium channels with properties of delayed rectifiers.
Yokoyama et al. (Mon,) reported a other. mRNAs derived from cloned cDNAs of NGK1 and NGK2 was evaluated on Formation of functional potassium channels. Injection of mRNAs derived from cloned cDNAs of NGK1 and NGK2 into Xenopus oocytes directed the formation of functional potassium channels with properties of delayed rectifiers.
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