Key result
Review outlines the protein C pathway and drotrecogin alfa use for severe sepsis.
Review explores drotrecogin alfa's role in managing severe sepsis in emergency departments, indicating its potential benefit.
Human protein C is a serine protease that circulates in the blood as an inactive zymogen. It is converted to its active form by interaction with thrombomodulin on the endothelial wall. Activated protein C has a significant role in maintaining haemostasis, and is a major mechanism of controlling microvascular thrombosis. Recent reports describe the use of drotrecogin alfa (recombinant activated protein C) in severe sepsis, a condition relevant to emergency medicine. This review describes the physiology of the protein C pathway and its importance in sepsis. It will also focus on the use of drotrecogin alfa in sepsis, and its use in the ED.
No takes yet. Share an insight, caveat, or question.
Adam McLeay (2004) conducted a review in Severe sepsis. Drotrecogin alfa (recombinant activated protein C) was evaluated. This review outlines the physiology of the protein C pathway and discusses the use of drotrecogin alfa for treating severe sepsis in the emergency department.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: