Key result
Plasma thrombomodulin, mainly smaller fragments of degraded forms, was increased in patients with DIC, pulmonary thromboembolism, ARDS, chronic renal failure, or acute hepatic failure.
Population
Patients with disseminated intravascular coagulation syndrome, pulmonary thromboembolism, adult respiratory…
Design
Cross-sectional
Authors
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Elevated thrombomodulin fragments may mark endothelial injury in these states; leaves open prospective validation as a clinical biomarker.
Observational
Plasma thrombomodulin levels, specifically smaller degraded fragments, are elevated in various disease states including DIC and pulmonary thromboembolism, suggesting accelerated release from endothelial cells.
Takano et al. (1990) conducted an observational in Disseminated intravascular coagulation syndrome, pulmonary thromboembolism, adult respiratory distress syndrome, chronic renal failure, or acute hepatic failure. Various disease states (DIC, pulmonary thromboembolism, ARDS, chronic renal failure, acute hepatic failure) vs. Healthy state was evaluated on Plasma concentrations of thrombomodulin. Plasma thrombomodulin, mainly smaller fragments of degraded forms, was increased in patients with DIC, pulmonary thromboembolism, ARDS, chronic renal failure, or acute hepatic failure.
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