Answers are grounded in this paper and cite their sources.
The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomimetic intramolecular Diels-Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substrate-controlled Yamamoto aldol reaction.
No takes yet. Share an insight, caveat, or question.
Weber et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: