Key result
Higher serum vitamin A is linked to ~2-fold higher odds of pediatric metabolic syndrome.
Why the study?
Associations between vitamin A and metabolic syndrome or other metabolic risk factors remain controversial in children and adolescents.
Does higher serum vitamin A increase the risk of metabolic syndrome in children and adolescents?
Cross-Sectional (n=3,025)
Yes
Does higher serum vitamin A increase the risk of metabolic syndrome in children and adolescents?
Higher serum vitamin A levels correlate with significantly increased odds of metabolic syndrome and related cardiovascular risk factors in Chinese children and adolescents.
Answers are grounded in this paper and cite their sources.
Should not change vitamin A guidance in youth; leaves open causal role in pediatric MetS.
Vitamin A, a fat-soluble essential vitamin, is implicated in a large range of physiological processes. Up to now, the associations between vitamin A and metabolic syndrome (MetS) or other metabolic risk factors are controversial in children and adolescents. Thus, we aimed to dig into the relationship of vitamin A with MetS and many other metabolic risk factors. This was a cross-sectional study derived from the China National Nutrition and Health Surveillance of Children and Lactating Mothers. A total of 3025 school-aged (7-17 years) children and adolescents were selected by applying multistage stratified cluster random sampling methods in the Jiangsu Province of eastern China. Through enquiry survey, anthropometric measurement and laboratory examination, relevant information and blood biochemical indexes of the participants were collected in this study. MetS was identified according to the modified criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). Multivariate logistic analysis and the generalized additive model (GAM) were used to analyze the relationship between vitamin A and various metabolic risk factors. The overweight, obesity and MetS prevalence of children and adolescents in this study was 14.0%, 11.9% and 5.1%, respectively. The risk of prevalent MetS, general obesity, high low-density lipoprotein (LDL), high total cholesterol (TC) and hyperuricemia increased with vitamin A in a dose-dependent way. Logistic regression analysis showed that serum vitamin A Z scores were positively associated with MetS and central obesity, elevated blood pressure (BP) and elevated triglyceride (TG). Sex stratification analysis showed that both in male and female participants, the risk of prevalent MetS, general obesity, high LDL, high TC and hyperuricemia still increased with vitamin A levels. MetS was at a high prevalence level in children and adolescents in Jiangsu that were 7-17 years old. Vitamin A was positively associated with obesity, MetS, dyslipidemia and hyperuricemia. More public health measures and new visions should focus on the effects of retinol on children and adolescents.
No takes yet. Share an insight, caveat, or question.
Tian et al. (2022) conducted a cross-sectional in Metabolic risk factors (n=3,025). Serum vitamin A vs. Lower serum vitamin A levels was evaluated on Metabolic syndrome (MetS) (OR 2.009, 95% CI 1.713-2.356). Higher serum vitamin A Z-scores were positively associated with metabolic syndrome (OR 2.009) in children and adolescents.
Synapse has enriched 10 related papers. Consider them for comparative context: