Key result
Adolescent metabolic syndrome is linked to elevated liver enzymes and cardiovascular risk markers.
Why the study?
The study was conducted to describe the prevalence of metabolic syndrome in adolescents and examine its association with several metabolic syndrome-related biochemical markers.
What is the prevalence of metabolic syndrome and its association with biochemical markers in adolescents in Beijing?
Cross-Sectional (n=1,766)
Yes
What is the prevalence of metabolic syndrome and its association with biochemical markers in adolescents in Beijing?
Metabolic syndrome is present in 3% of Beijing adolescents and is strongly associated with adverse biochemical markers, highlighting the need for early intervention to reduce future cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Metabolic syndrome in Beijing adolescents supports biomarker monitoring in at-risk youth; leaves open causal links and need for longitudinal validation.
Objective: To describe the prevalence of metabolic syndrome (MetS) in adolescents and its association with several MetS-related biochemical markers. Methods: A cross-sectional analysis was carried out and data were extracted from the Nutrition and Health Surveillance in Primary and Secondary school students of Beijing (NHSPSB) 2017. Participants were aged 10–15 years old. MetS was diagnosed using the recommended criteria for Chinese adolescents. The associations among MetS, biochemical biomarkers, and socioeconomic status were estimated by multivariable linear regression. Results: The prevalence of MetS in adolescents in Beijing was 3% in the total sample, 4% in boys, and 2% in girls. Moreover, the prevalence of MetS in the overweight and obesity populations were 5% and 12% respectively. The prevalence of MetS remained higher in boys than in girls. The concentrations of alanine aminotransferase (ALT), serum uric acid (SUA), low density lipoprotein (LDL), and C-reactive protein (CRP) were higher in the MetS children in comparison with non-MetS children (All p < 0.05), while the high-density lipoprotein (HDL) concentration was lower in MetS children. After adjusting for socioeconomic parameters in the multivariable regression model, MetS was strongly associated with ALT, SUA, HDL, and LDL. The five components of MetS indicated that abdominal obesity and a high serum triglyceride (TG) concentration were tightly linked with ALT, SUA, LDL, and CRP; while a low HDL concentration and elevated blood pressure were related to enhanced ALT, UA, and CRP. Additionally, impaired fasting glucose was only related to increased ALT. Conclusion: The epidemiological issues of MetS in Beijing adolescents should be known across socioeconomic classes. Early intervention strategies, such as dietary pattern interventions and physical excise, should be designed for that population to reduce the disease burdens of cardiovascular disease (CVD), Type 2 diabetes (T2D), and steatohepatitis in adulthood.
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Zhao et al. (2019) conducted a cross-sectional in Metabolic Syndrome (n=1,766). Metabolic syndrome vs. No metabolic syndrome was evaluated on Alanine aminotransferase (ALT) concentration (p=<0.05). Metabolic syndrome was present in 3% of adolescents and was significantly associated with elevated levels of ALT, serum uric acid, LDL, and CRP compared to those without the syndrome.
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