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August 31, 2017BloodOpen Access

H3 K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

Bernhard Lehnertz Yu Wei Zhang Isabel Boivin Nadine Mayotte Elisa Tomellini Jalila Chagraoui Vincent‐Philippe Lavallée Josée Hébert Guy Sauvageau

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Abstract

mutations are strong disease accelerators in a RUNX1-RUNX1T1 AML mouse model, suggesting that H3K27me2/3 has an important and selective leukemia-suppressive activity in this genetic context.

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Lehnertz et al. (2017) studied this question.

synapsesocial.com/papers/6a62d42d23e6741936094083 https://doi.org/10.1182/blood-2017-03-774653

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