Key result
Hypertension is linked to an exaggerated blood pressure response during ischemic exercise in older adults.
Why the study?
Whether hypertension further enhances aging-induced augmented blood pressure response to ischemic dynamic exercise had not yet been investigated.
Does hypertension exacerbate the blood pressure response to ischemic dynamic exercise in older adults?
Cross-Sectional (n=23)
not blinded
Does hypertension exacerbate the blood pressure response to ischemic dynamic exercise in older adults?
Absolute Event Rate: 48% vs 34%
p-value: p=0.007
Older adults with hypertension demonstrate an exaggerated blood pressure response to ischemic dynamic exercise, highlighting a potential mechanism for increased cardiovascular risk during daily physical activities.
Hypertension may heighten BP surges during ischemic exercise in older adults; hypothesis-generating cross-sectional finding requiring prospective validation.
Hypertension is known to augment exercise blood pressure (BP). Aging also potentiates BP response to ischemic dynamic exercise. However, whether hypertension further enhances aging-induced augmented BP response to ischemic dynamic exercise has not yet been investigated. Therefore, we aimed to test the hypothesis that hypertension exacerbates the pressor response to ischemic dynamic exercise in older adults. The participants were classified into the following two groups: nonhypertensive (NHT, n = 13, 60-80 years) and hypertensive (HT, n = 10, 61-78 years). We compared the BP responses to very light-intensity rhythmic handgrip exercise during post-isometric handgrip exercise muscle ischemia (PEMI) simulated as ischemic dynamic exercise between the HT and NHT groups. Both systolic BP (SBP) and diastolic BP (DBP) responses to the rhythmic handgrip exercise during PEMI in the HT group (∆SBP: 48 ± 18 mmHg and ∆DBP: 28 ± 10 mmHg, p = 0.007) were significantly higher than those in the NHT group (∆SBP: 34 ± 17 mmHg and ∆DBP: 20 ± 6 mmHg, p = 0.003). Importantly, resting SBP was a significant independent determinant of DBP response to the rhythmic handgrip exercise during PEMI (β = 0.412, p = 0.047). These results suggest that hypertension further elevates the heightened BP response to ischemic dynamic exercise in older adults.
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Hasegawa et al. (2025) conducted a cross-sectional in Hypertension (n=23). Hypertension vs. Nonhypertensive older adults was evaluated on Systolic blood pressure response (ΔSBP) to rhythmic handgrip exercise during post-exercise muscle ischemia (PEMI) (p=0.007). Hypertension significantly exacerbated the systolic and diastolic blood pressure responses to ischemic dynamic exercise in older adults.
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