Key result
Cinaciguat treatment improved histopathological lesions, cardiac performance, and reduced oxidative stress in experimentally induced myocardial infarction in rats and a canine model.
Why the study?
Does cinaciguat improve cardiac function and reduce ischemic injury in animal models of myocardial infarction?
Population
Rats with isoproterenol-induced myocardial infarction, isolated canine coronary arterial rings exposed to…
Comparison
Cinaciguat vs Vehicle
Design
Preclinical
Follow-up
4 days (in rat model)
Authors
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Hypothesis-generating for soluble guanylate cyclase activation in ischemic heart disease; does not support clinical use without human trials.
Does cinaciguat improve cardiac function and reduce ischemic injury in animal models of myocardial infarction?
Pharmacological activation of soluble guanylate cyclase with cinaciguat protects against ischemic injury in rat and canine models, suggesting a potential novel approach for ischemic heart disease.
Korkmaz et al. (2009) studied Myocardial infarction. Cinaciguat vs. Vehicle was evaluated on Histopathological lesions, cardiac performance, oxidative stress, and gene expression. Cinaciguat treatment improved histopathological lesions, cardiac performance, and reduced oxidative stress in experimentally induced myocardial infarction in rats and a canine model.
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