Key result
Multiple drugs with orthostatic potential (OR 1.22; 95% CI 1.08-1.37), SSRIs (OR 2.09), and TCAs (OR 4.36) were significantly associated with orthostatic hypotension in older adults.
Why the study?
Is specific drug therapy associated with an increased risk of orthostatic hypotension in elderly outpatients?
Population
571 elderly patients assessed in an outpatient comprehensive geriatric assessment unit over a 9-year period…
Comparison
Drug therapy, specifically polypharmacy and use… vs Fewer medications or absence of the specific…
Design
Cross-sectional
Authors
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Orthostatic hypotension screening in elderly outpatients may flag modifiable risks; leaves open whether it alters falls or management in practice.
Cross-Sectional (n=571)
No
Is specific drug therapy associated with an increased risk of orthostatic hypotension in elderly outpatients?
Odds Ratio: 1.22 (95% CI 1.08–1.37)
In elderly outpatients, polypharmacy and specific drug classes including alpha-blockers, calcium channel blockers, and antidepressants are significantly associated with orthostatic hypotension.
Press et al. (2015) conducted a cross-sectional in Orthostatic hypotension (n=571). Multiple drugs with the potential to cause orthostatic hypotension vs. Fewer or no such drugs was evaluated on Orthostatic hypotension (OR 1.22, 95% CI 1.08-1.37). Multiple drugs with orthostatic potential (OR 1.22; 95% CI 1.08-1.37), SSRIs (OR 2.09), and TCAs (OR 4.36) were significantly associated with orthostatic hypotension in older adults.
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