Key result
Dobutamine induced the highest increase in ventricular myocardium and skeletal muscle blood flow, while milrinone decreased vascular resistance moderately in most organs.
Why the study?
What are the comparative effects of dopamine, dobutamine, amrinone, and milrinone on regional blood flow in isoflurane-anesthetized dogs?
What are the comparative effects of dopamine, dobutamine, amrinone, and milrinone on regional blood flow in isoflurane-anesthetized dogs?
In a canine model, milrinone demonstrated a favorable profile by decreasing vascular resistance in most organs while increasing myocardial blood flow, suggesting potential utility in heart failure with excessive vasoconstriction.
Animal data on inotrope perfusion effects are hypothesis-generating; leaves open translation to human heart failure management.
The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs. Dopamine increased blood flow in ventricular myocardium. Furthermore dopamine induced the increase in blood flow in intestine and kidney at low to middle dose, but not at high dose. Dobutamine induced the highest increase in blood flow in ventricular myocardium and skeletal muscle among the drugs evaluated at middle and high doses. Amrinone and milrinone increased blood flow in ventricular myocardium almost same with catecholamines, and milrinone decreased vascular resistance moderately in most other organs. Milrinone might be more useful than catecholamines for improvement of congestive heart failure or peripheral circulatory failure accompanied with exceeded vasoconstriction.
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TOBATA et al. (2004) studied Healthy (anesthetized dogs) (n=28). Dopamine, dobutamine, amrinone, and milrinone vs. Baseline was evaluated on Regional blood flow in various organs. Dobutamine induced the highest increase in ventricular myocardium and skeletal muscle blood flow, while milrinone decreased vascular resistance moderately in most organs.
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