Population
11 anesthetised rabbits and 8 guinea pig isolated atria
Design
Preclinical
Authors
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Caution against direct clinical translation of these agent-specific effects; leaves open the need for human trials to guide inotrope selection.
In animal models, adrenaline acts as an inoconstrictor, dobutamine as an inodilator, and milrinone predominantly as a vasodilator with weak inotropic effects.
Royse et al. (2007) studied this question.
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