What question did this study set out to answer?

The study aims to explore how milrinone affects the electrophysiological properties of cardiac tissue from dogs and guinea pigs.

September 1, 1985Journal of Cardiovascular Pharmacology

The Effect of Milrinone (Win 47203) on the In Vitro Electropharmacological Properties of Mammalian Cardiac Tissue

View Full Paper

Ask AI

Bookmark

Population

Dog and guinea pig cardiac muscle (Purkinje fibers, auricular and ventricular trabeculae, papillary muscle)

Design

Preclinical

Authors

PCPaul C. CanniffConnecticut Sea Grant AFA. FarahSohag University NSN. SperelakisTexas Tech University

Discussion

Member takes

Implication

May alter excitability in depolarized myocardium; leaves open translation to human arrhythmia risk.

Key Points

The study aims to explore how milrinone affects the electrophysiological properties of cardiac tissue from dogs and guinea pigs.
Microelectrode techniques were used on dog and guinea pig cardiac muscle to assess electrophysiological changes resulting from milrinone.
Cardiac muscle samples included Purkinje fibers, auricular and ventricular trabeculae, and papillary muscles bathed in various K+ concentrations.
Dose-response relationships were evaluated in terms of action potential characteristics and contractility.
Milrinone increased action potential amplitude and overshoot in dog auricular and ventricular trabeculae, while decreasing action potential duration and effective refractory period.
In guinea pig papillary muscle, milrinone produced dose-dependent increases in slow action potentials and contractions, reversible upon washing.
Depolarized Purkinje fibers and trabeculae exhibited slow action potentials in response to milrinone, influenced by its concentration.

Structured PICO

Population

Dog and guinea pig cardiac muscle (Purkinje fibers, auricular and ventricular trabeculae, papillary muscle)

Intervention

Milrinone (Win 47203)

Outcome

Electropharmacological properties (action potential configuration, amplitude, duration, effective refractory period, slow action potentials)surrogate

Milrinone demonstrates specific electropharmacological effects on mammalian cardiac tissue, including the induction of slow action potentials in depolarized muscle.

Cite This Study

Canniff et al. (1985) studied this question.

synapsesocial.com/papers/6a7190d1b5c1fe5ca9dfdcf7 https://doi.org/10.1097/00005344-198509000-00001

View Full Paper

Ask AI

Bookmark

The Effect of Milrinone (Win 47203) on the In Vitro Electropharmacological Properties of Mammalian Cardiac Tissue

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Effect of Milrinone (Win 47203) on the In Vitro Electropharmacological Properties of Mammalian Cardiac Tissue

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider