Key result
In isolated guinea pig papillary muscles, milrinone-induced positive inotropy correlated significantly with cAMP content (r=0.72, p<0.05) and cAPK activation (r=0.79, p<0.001).
Population
Isolated guinea pig cardiac muscle (papillary muscles)
Comparison
Milrinone (0.1-1000 μM) vs Isoproterenol (3 nM), ouabain, or Bay K-8644
Design
Preclinical
Authors
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Should not change milrinone use in patients; hypothesis-generating for cAMP-PDE mechanisms in cardiac muscle.
p-value: p=<0.05
Milrinone exerts positive inotropic effects in cardiac muscle via selective inhibition of PDE isozymes and subsequent activation of the cAMP system.
Silver et al. (1989) studied Isolated guinea pig cardiac muscle. Milrinone vs. Isoproterenol, ouabain, Bay K-8644 was evaluated on Correlation between isometric force development and cAMP content or cAPK activity ratio (p=<0.05). In isolated guinea pig papillary muscles, milrinone-induced positive inotropy correlated significantly with cAMP content (r=0.72, p<0.05) and cAPK activation (r=0.79, p<0.001).
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