May 1, 1984Circulation
The effects of milrinone on conduction, reflection, and automaticity in canine Purkinje fibers.
Why the study?
Does milrinone alter conduction, reflection, and automaticity in canine Purkinje fibers?
Population
Canine false tendons homogeneously superfused with either normal or high-K Tyrode's solution and Purkinje…
Comparison
Milrinone (0.2 to 20 micrograms/ml) vs Baseline/control conditions
Design
Preclinical
Authors
Discussion
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Implication
May improve conduction in ischemic tissue with variable reentry effects; hypothesis-generating for arrhythmia mechanisms, not yet informing practice.
Structured PICO
Does milrinone alter conduction, reflection, and automaticity in canine Purkinje fibers?
P
Population
Canine false tendons homogeneously superfused with either normal or high-K Tyrode's solution and Purkinje fibers mounted in a three-compartment chamber with an 'ischemic' central segment
I
Intervention
Milrinone (0.2 to 20 micrograms/ml)
C
Comparator
Baseline/control conditions (normal Tyrode's solution)
O
Outcome
Electrophysiologic effects including action potential characteristics, refractoriness, conduction velocity, reflected reentry, and automaticitysurrogate
Milrinone produces significant electrophysiologic effects in canine Purkinje fibers, improving conduction in depressed areas which may lead to either antiarrhythmic or arrhythmogenic outcomes.
Cite This Study
Davidenko et al. (1984) studied this question.