April 1, 1990Journal of Cardiovascular Electrophysiology
Effects of Milrinone on Atrioventricular Conduction in the Canine Heart Under Normal Conditions, During Atrial Flutter and After Ligation and Reperfusion of the Septal Artery
Key result
Milrinone improved AV conduction in 5 of 6 dogs with ischemia-induced AV block, but caused dose-dependent increases in ventricular rate during atrial flutter.
Why the study?
Does milrinone modulate atrioventricular conduction in canine models under normal conditions, atrial flutter, and ischemia?
Population
Anesthetized dogs (n=11 for ligation/reperfusion study)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May accelerate ventricular rates in atrial flutter; leaves open benefit for ischemia-induced AV block in humans.
Structured PICO
Does milrinone modulate atrioventricular conduction in canine models under normal conditions, atrial flutter, and ischemia?
P
Population
11 anesthetized dogs evaluated for the effects of milrinone on AV conduction under normal conditions, during atrial flutter, and after septal artery ligation and reperfusion.
I
Intervention
Milrinone (10-100 μg/kg, IV bolus)
O
Outcome
Atrioventricular (AV) nodal conduction parameters (PR interval, Wenckebach cycle length, AV nodal refractory period)surrogate
Milrinone facilitates AV nodal conduction and abbreviates refractoriness, which can reverse ischemia-induced AV block but may dangerously accelerate ventricular rates during atrial flutter.
Cite This Study
Davidenko et al. (1990) studied Atrioventricular conduction disturbances (n=11). Milrinone was evaluated on Atrioventricular (AV) nodal conduction. Milrinone improved AV conduction in 5 of 6 dogs with ischemia-induced AV block, but caused dose-dependent increases in ventricular rate during atrial flutter.