Why the study?
Does milrinone directly affect contractility in skinned skeletal muscle fibers?
Does milrinone directly affect contractility in skinned skeletal muscle fibers?
Milrinone directly inhibits contractility in skeletal muscle fibers, suggesting its positive inotropic effect on cardiac muscle is likely not due to direct action on muscle cross bridges.
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May indicate off-target skeletal effects; leaves open cardiac inotropy mechanisms beyond cross-bridge action in vivo.
Seow et al. (1998) studied this question.
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