Key result
Milrinone decreased the time constant of left ventricular pressure decay significantly more than dobutamine (19.9% vs 6.9%; P < 0.05), indicating improved left ventricular relaxation.
Why the study?
Does milrinone improve left ventricular relaxation and sarcoplasmic reticulum Ca2+ uptake compared to dobutamine?
Population
In vivo left ventricular model and cardiac sarcoplasmic reticulum (SR) vesicles purified from LV muscles
Comparison
Milrinone (10 microg/kg) vs Dobutamine (3 microg x kg(-1) x min(-1))
Design
Preclinical
Authors
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Milrinone may enhance LV relaxation more than dobutamine in animals; leaves open clinical translation and SR Ca2+ effects.
Does milrinone improve left ventricular relaxation and sarcoplasmic reticulum Ca2+ uptake compared to dobutamine?
Absolute Event Rate: 19.9% vs 6.9%
p-value: p=< 0.05
Milrinone substantially improves left ventricular relaxation by accelerating SR Ca2+-ATPase activity and Ca2+ uptake, likely via local cAMP elevation from PDE3 inhibition.
Yano et al. (2000) studied this question. Milrinone vs. Dobutamine was evaluated on Time constant (tau) of LV pressure decay (p=< 0.05). Milrinone decreased the time constant of left ventricular pressure decay significantly more than dobutamine (19.9% vs 6.9%; P < 0.05), indicating improved left ventricular relaxation.
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