What does this research mean for the field?

Rhinovirus infection causes significantly more severe lower respiratory illness and airway inflammation in asthmatic individuals compared to healthy controls, which is strongly driven by virus load and an imbalance of augmented Th2 or impaired Th1 and IL-10 immune responses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate the relationship between rhinovirus infection, cytokine responses, and asthma exacerbations.

September 3, 2008Proceedings of the National Academy of SciencesOpen Access

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

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Investigate the relationship between rhinovirus infection, cytokine responses, and asthma exacerbations.
Experimental rhinovirus infection in 10 asthmatic and 15 normal volunteers.
Assessment of clinical symptoms, lung function, and immune responses in blood and bronchial samples.
Measurement of virus load and immune cytokines post-infection.
Asthmatic subjects showed significantly greater lower respiratory symptoms compared to normals following rhinovirus infection.
In asthmatics, higher virus load correlated with increased lower respiratory symptoms, bronchial hyperreactivity, and reduced lymphocyte counts.
Impaired Th1 IL-10 responses and elevated Th2 cytokines were linked to greater lung function impairment and eosinophilic inflammation.

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Implication

Randomized trial reveals asthma exacerbation severity relates to virus load and immune response in asthmatics, suggesting potential treatment avenues.

Cite This Study

Message et al. (2008) studied this question.

synapsesocial.com/papers/6a62dacf50e2b8a4ef6a748a https://doi.org/10.1073/pnas.0804181105

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Implication

Randomized trial reveals asthma exacerbation severity relates to virus load and immune response in asthmatics, suggesting potential treatment avenues.

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

Key Points

Discussion

Implication

Cite This Study

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

Key Points

Discussion

Implication

Cite This Study

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