Key result
Among 1,151 patients with hand, foot and mouth disease in Jiujiang, China, 19.6% were infected with coxsackievirus A16, which predominantly belonged to the B1b subgenotype.
Cross-Sectional (n=1,151)
No
The study identifies the B1b subgenotype as the circulating CA16 strain in the studied HFMD patients, providing data for targeted intervention mechanisms.
CA16 molecular surveillance in HFMD supports monitoring; leaves open targeted prevention until confirmed in larger studies.
The hand, foot and mouth disease (HFMD) epidemics have mainly been caused by human enterovirus 71 and human coxsackievirus A16 (CA16), which circulated alternatively or together in the epidemic area. The aim of the present study was to provide guidance in the prevention and control of HFMD from CA16 infection. The molecular epidemiology of the human CA16 strains was investigated. Overall, 1,151 specimens (throat swabs) were collected from 1,151 patients with HFMD symptoms. The results of the homology comparison in the VP1 of CA16 strains showed that the CA16 strains belonged to the B1b subgenotype. The difference of the 6 CA16 strains analyzed showed that the most prominent strain was the A genotype, and the most close strains were the B1 gene subtype, particularly the B1b gene subtype. With regards to the amino acids, in addition to the A genotype, the differences of amino acids with other gene subtype was not significant. The present data suggest that more effective and highly targeted intervention mechanisms could be developed for the prevention and control of HFMD.
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Yu et al. (2016) conducted a cross-sectional in Hand, foot and mouth disease (HFMD) (n=1,151). Coxsackievirus A16 (CA16) infection was evaluated on Prevalence and genotype of CA16 infection. Among 1,151 patients with hand, foot and mouth disease in Jiujiang, China, 19.6% were infected with coxsackievirus A16, which predominantly belonged to the B1b subgenotype.
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