Key result
Genomic sequencing identifies GDV126 as a recombinant Coxsackievirus A16 with different cell tropism from EV71.
The identification of a novel recombinant Coxsackievirus A16 strain highlights the genetic variations and evolution of HFMD pathogens.
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Recombinant CoxA16 strain in animals raises no immediate clinical changes; leaves open questions on HFMD evolution and human tropism.
Enterovirus 71 (EV71) and Coxsackievirus A16 (CoxA16) are two major pathogens of Hand, foot and mouth disease (HFMD) that epidemic periodically among children and cause deaths occasionally. There is no effective vaccine or drug for HFMD to date. Here the whole genome of a clinic virus isolate GDV126（China Center for Type Culture Collection, CCTCC）of HFMD was sequenced in Hubei 2010. Phylogenetic analysis demonstrates that the virus belongs to CoxA16. Both phylogenetic and recombination analysis of GDV126 showed that the GDV126 was a recombinant strain of CoxA16. In addition, GDV126 had different cell tropism from EV71. This work demonstrated the genetic variations and evolution of the HFMD pathogens and implicated complication to prevent the disease.
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Tingting Xu (2016) studied Hand, foot and mouth disease (HFMD) (n=1). Whole genome sequencing and phylogenetic analysis vs. EV71 was evaluated on Phylogenetic and recombination analysis. Whole genome sequencing and phylogenetic analysis of a clinical HFMD sample identified GDV126 as a recombinant strain of Coxsackievirus A16 with different cell tropism from EV71.
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