January 1, 1996Japanese Heart JournalOpen Access

In hypercholesterolemic rabbits, gemfibrozil supplementation paradoxically increased intimal thickening by 33% compared with controls 4 weeks after balloon-induced arterial injury.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Balloon-induced arterial injury with hyperlipidemia (n=67). Intervention: Gemfibrozil vs. Normal chow or high-cholesterol diet without gemfibrozil. Primary outcome: Intimal thickening area 4 weeks after injury (33% increase, p=<0.05).

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Why the study?

Does gemfibrozil attenuate intimal thickening after balloon-induced arterial injury in hypercholesterolemic rabbits?

Population

New Zealand white rabbits subjected to balloon-induced carotid injury

Comparison

Gemfibrozil added to a 0.25%… vs Chow diet or 0.25% cholesterol-enriched diet…

Design

Preclinical

Follow-up

4 weeks after injury

Key result

In hypercholesterolemic rabbits, gemfibrozil supplementation paradoxically increased intimal thickening by 33% compared with controls 4 weeks after balloon-induced arterial injury.

Authors

CLCraig H. Lundgren BSBurton E. Sobel SFSatoshi Fujii

Discussion

Member takes

Overview

Gemfibrozil does not attenuate post-injury intimal thickening in hypercholesterolemic rabbits; leaves open effects on human restenosis.

Structured PICO

Does gemfibrozil attenuate intimal thickening after balloon-induced arterial injury in hypercholesterolemic rabbits?

Population

67 New Zealand white rabbits subjected to balloon-induced carotid injury and fed either normal chow, a high-cholesterol diet, or a high-cholesterol diet supplemented with gemfibrozil for 5 weeks.

Intervention

Gemfibrozil (0.05%, 0.1%, or 0.02%) added to a 0.25% cholesterol-enriched diet for 1 week prior to and 4 weeks after balloon-induced carotid injury

Comparator

Chow diet (control) or 0.25% cholesterol-enriched diet without gemfibrozil

Outcome

Intimal thickening area [intima (mm2)/(intima + media (mm2))] at 4 weeks after injurysurrogate

Main Result

Effect estimate: 33% increase

Absolute Event Rate: 35.9% vs 27%

p-value: p=<0.05

Gemfibrozil did not attenuate intimal thickening after balloon injury in hypercholesterolemic rabbits, though it prevented thrombotic luminal occlusion.

Limitations

Small sample size of each gemfibrozil dose group
Short duration of feeding and therapy insufficient for sustained lipid reduction
Modest amount of cholesterol in the chow

Cite This Study

Lundgren et al. (1996) studied Balloon-induced arterial injury with hyperlipidemia (n=67). Gemfibrozil vs. Normal chow or high-cholesterol diet without gemfibrozil was evaluated on Intimal thickening area 4 weeks after injury (33% increase, p=<0.05). In hypercholesterolemic rabbits, gemfibrozil supplementation paradoxically increased intimal thickening by 33% compared with controls 4 weeks after balloon-induced arterial injury.

synapsesocial.com/papers/6a62db2923e6741936094404 https://doi.org/10.1536/ihj.37.119

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January 1, 1996Japanese Heart JournalOpen Access

In hypercholesterolemic rabbits, gemfibrozil supplementation paradoxically increased intimal thickening by 33% compared with controls 4 weeks after balloon-induced arterial injury.

View Full Paper

Ask AI

Bookmark

Why the study?

Does gemfibrozil attenuate intimal thickening after balloon-induced arterial injury in hypercholesterolemic rabbits?

Population

New Zealand white rabbits subjected to balloon-induced carotid injury

Comparison

Gemfibrozil added to a 0.25%… vs Chow diet or 0.25% cholesterol-enriched diet…

Design

Preclinical

Follow-up

4 weeks after injury

Key result

In hypercholesterolemic rabbits, gemfibrozil supplementation paradoxically increased intimal thickening by 33% compared with controls 4 weeks after balloon-induced arterial injury.

Authors

CLCraig H. Lundgren BSBurton E. Sobel SFSatoshi Fujii

Discussion

Member takes

Overview

Gemfibrozil does not attenuate post-injury intimal thickening in hypercholesterolemic rabbits; leaves open effects on human restenosis.

Structured PICO

Does gemfibrozil attenuate intimal thickening after balloon-induced arterial injury in hypercholesterolemic rabbits?

Population

67 New Zealand white rabbits subjected to balloon-induced carotid injury and fed either normal chow, a high-cholesterol diet, or a high-cholesterol diet supplemented with gemfibrozil for 5 weeks.

Intervention

Gemfibrozil (0.05%, 0.1%, or 0.02%) added to a 0.25% cholesterol-enriched diet for 1 week prior to and 4 weeks after balloon-induced carotid injury

Comparator

Chow diet (control) or 0.25% cholesterol-enriched diet without gemfibrozil

Outcome

Intimal thickening area [intima (mm2)/(intima + media (mm2))] at 4 weeks after injurysurrogate

Main Result

Effect estimate: 33% increase

Absolute Event Rate: 35.9% vs 27%

p-value: p=<0.05

Gemfibrozil did not attenuate intimal thickening after balloon injury in hypercholesterolemic rabbits, though it prevented thrombotic luminal occlusion.

Limitations

Small sample size of each gemfibrozil dose group
Short duration of feeding and therapy insufficient for sustained lipid reduction
Modest amount of cholesterol in the chow

Cite This Study

synapsesocial.com/papers/6a62db2923e6741936094404 https://doi.org/10.1536/ihj.37.119

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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