Key result
Continuous dual Doppler flow velocity documented dipyridamole-induced coronary steal, reversal by aminophylline, and normalization after successful coronary angioplasty in a single patient.
Case Report (n=1)
Continuous dual flowire spectral coronary flow determinations can quantitatively verify mechanisms of pharmacologic and mechanical stimuli on coronary blood flow, such as dipyridamole-induced coronary steal.
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Documents epicardial steal and its reversal; leaves open prevalence, mechanisms, and any role in guiding interventions.
In the course of studying the effects of coronary angioplasty on branch vessel flow using two Doppler flow velocity guidewires, we quantitated simultaneous blood flow responses proximal and distal to a stenosis. The alterations of flow documented a horizontal epicardial steal induced during dipyridamole hyperemia, hyperemic flow reversal by intravenous aminophylline, and subsequent normalization of distal hyperemia after endoluminal enlargement by successful angioplasty. The quantitative physiology of the patient described here confirms one postulated mechanism of abnormal myocardial perfusion stress scintigraphy. Continuous dual flowire spectral coronary flow determinations appear to be a valuable method in verifying postulated mechanisms of various pharmacologic and mechanical stimuli influencing coronary blood flow in patients with atherosclerotic coronary artery disease.
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Kern et al. (1993) conducted a case report in Atherosclerotic coronary artery disease (n=1). Coronary angioplasty and pharmacologic stimuli (dipyridamole, aminophylline) was evaluated on Simultaneous blood flow responses proximal and distal to a stenosis. Continuous dual Doppler flow velocity documented dipyridamole-induced coronary steal, reversal by aminophylline, and normalization after successful coronary angioplasty in a single patient.
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