July 1, 1992HeartOpen Access

Vasodilator myocardial perfusion imaging: demonstration of local electrophysiological changes of ischaemia

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Why the study?

Does dipyridamole infusion induce local electrophysiological changes indicative of ischemia in regions with reversible perfusion defects?

Population

31 men undergoing routine cardiac catheterisation for investigation of chest pain at a tertiary cardiac…

Comparison

Intravenous infusion of dipyridamole for four… vs Internal comparison between myocardial regions…

Design

Cohort

Follow-up

Acute (during catheterization)

Authors

RJRoy M. JohnElectrophysiology PTPeter TaggartUniversity College London PSPeter SuttonLehigh Valley Hospital-Pocono

Discussion

Member takes

Implication

Dipyridamole-induced APD shortening supports local ischemia in collateral-dependent defects; hypothesis-generating for stress-test mechanisms and needs prospective validation.

Structured PICO

Does dipyridamole infusion induce local electrophysiological changes indicative of ischemia in regions with reversible perfusion defects?

Population

31 men undergoing routine cardiac catheterisation for investigation of chest pain at a tertiary cardiac referral centre.

Intervention

Intravenous infusion of dipyridamole (0.015 mg/kg/min) for four minutes with atrial pacing at 20% above resting rate, followed by Technetium-99m MIBI and single photon emission tomographic imaging, with endocardial recordings of steady state monophasic action potentials.

Comparator

Internal comparison between myocardial regions: normal perfusion pattern (group 1) vs. perfusion defect with narrowed arteries (group 2) vs. perfusion defect with occluded arteries and collaterals (group 3).

Outcome

Changes in the duration of the steady state monophasic action potential indicative of early localised myocardial ischaemia.surrogate

Dipyridamole induces true local myocardial ischemia in regions with reversible perfusion defects, particularly when viability depends on collateral circulation.

Cite This Study

John et al. (1992) studied this question.

synapsesocial.com/papers/6a8b188cf71b672e3df46757 https://doi.org/10.1136/hrt.68.7.21

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Implication

Dipyridamole-induced APD shortening supports local ischemia in collateral-dependent defects; hypothesis-generating for stress-test mechanisms and needs prospective validation.

Vasodilator myocardial perfusion imaging: demonstration of local electrophysiological changes of ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vasodilator myocardial perfusion imaging: demonstration of local electrophysiological changes of ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider