Key result
Dipyridamole stress echocardiography demonstrated significantly lower sensitivity for detecting coronary artery disease compared to Tc-99m sestamibi SPECT (21% vs 52%, P=0.001).
Why the study?
Does high-dose dipyridamole stress echocardiography have lower sensitivity than Tc-99m sestamibi SPECT for detecting mild-to-moderate coronary artery disease?
Population
46 patients with coronary artery diameter stenosis >50% and <=90% in one or two epicardial coronary…
Comparison
High-dose dipyridamole stress echocardiography vs Tc-99m sestamibi SPECT performed simultaneously
Design
Cross-sectional
Authors
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Dipyridamole stress echo may miss mild CAD more often than SPECT; cross-sectional data leaves comparative accuracy open for prospective validation.
Cross-Sectional (n=46)
Does high-dose dipyridamole stress echocardiography have lower sensitivity than Tc-99m sestamibi SPECT for detecting mild-to-moderate coronary artery disease?
Absolute Event Rate: 21% vs 52%
p-value: p=0.001
Vasodilator stress with dipyridamole is significantly less sensitive for detecting mild-to-moderate coronary artery disease when using regional wall thickening (echocardiography) compared to perfusion defects (SPECT).
Soman et al. (2004) conducted a cross-sectional in Mild-to-moderate coronary artery disease (n=46). Dipyridamole stress echocardiography vs. Tc-99m sestamibi SPECT was evaluated on Sensitivity for the detection of coronary artery disease (p=0.001). Dipyridamole stress echocardiography demonstrated significantly lower sensitivity for detecting coronary artery disease compared to Tc-99m sestamibi SPECT (21% vs 52%, P=0.001).
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