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SUMMARY: Spermine was found to inhibit the growth of various micro-organisms. The most susceptible were Staphylococcus aureus and Staph. albus, Neisseria gonorrhoeae and N. meningitidis, and to a lesser degree Bacillus anthracis. The Enterobacteriaceae were relatively resistant. The action of spermine was enhanced by an increase in pH of the medium. The antibacterial effect was bactericidal; it was slowed but not prevented by a decrease in temperature from 37 to 6°. The nutrients of various media influenced the action of spermine.
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Rozansky et al. (1954) studied this question.
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