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This research aims to differentiate adult-onset Still's disease from bacterial sepsis using clinical manifestations and cytokine profiles.

September 1, 2010The Journal of RheumatologyOpen Access

Clinical Manifestations but not Cytokine Profiles Differentiate Adult-onset Still’s Disease and Sepsis

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This research aims to differentiate adult-onset Still's disease from bacterial sepsis using clinical manifestations and cytokine profiles.
Compared 22 patients with first flare and 6 chronic AOSD patients with 14 patients with bacterial sepsis.
Clinical manifestations were scored using a modified Pouchot score incorporating serum ferritin levels.
Serum cytokine levels were analyzed for both groups.
Active untreated AOSD had a higher modified Pouchot score (mean 5.60) compared to chronic AOSD (mean 1.16; p < 0.001) and sepsis (mean 2.38; p < 0.001).
A modified Pouchot score ≥ 4 achieved 92% sensitivity and 93% specificity for active AOSD.
Cytokines IL-6 and IL-8 were significantly elevated in sepsis, limiting cytokine use for differential diagnosis.

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Randomized trial analyzes clinical symptoms and cytokine levels to differentiate AOSD from sepsis, suggesting a better diagnostic approach.

Rau et al. (2010) studied this question.

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Randomized trial analyzes clinical symptoms and cytokine levels to differentiate AOSD from sepsis, suggesting a better diagnostic approach.