Key result
Women exhibited a blunted splanchnic vasoconstrictor response during head-up tilt compared to men (SpVC decrease 1.70 vs 4.81 ml/min/mmHg), tending to have lower orthostatic tolerance.
Why the study?
Do women have less splanchnic vasoconstriction during head-up tilt compared to men, leading to lower orthostatic tolerance?
Population
30 healthy individuals (14 women, mean age 23 +/- 6 years; 16 men, mean age 23 +/- 5 years)
Comparison
70 degree head-up tilt (HUT) for up to 45 minutes vs Supine baseline conditions and comparison…
Design
Other
Follow-up
45 minutes
Authors
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Women showed smaller splanchnic vasoconstrictor reserve during tilt; leaves open its causal role in sex differences in orthostatic tolerance.
Observational (n=30)
Do women have less splanchnic vasoconstriction during head-up tilt compared to men, leading to lower orthostatic tolerance?
Absolute Event Rate: 1.7% vs 4.81%
Women exhibit a blunted splanchnic vasoconstrictor response during orthostatic stress compared to men, which may contribute to their lower orthostatic tolerance.
Jarvis et al. (2009) conducted an observational in Healthy (n=30). Female sex vs. Male sex was evaluated on Decrease in splanchnic vascular conductance (SpVC) from baseline to tilt. Women exhibited a blunted splanchnic vasoconstrictor response during head-up tilt compared to men (SpVC decrease 1.70 vs 4.81 ml/min/mmHg), tending to have lower orthostatic tolerance.
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