In the preparation of theophylline cocrystals, phenol coformers facilitate water assimilation due to their weaker O–H⋯N(imidazole) synthon. The presence of –COOH prevents water incorporation and provides added physical stability at high humidity. This study shows the feasibility of cocrystal design of an API to tune physical properties based on hydrogen bond synthons.
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Sarma et al. (2014) studied this question.
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