February 6, 2014Journal of the American Chemical Society144 citations
View Full PaperIridium-Catalyzed Enantioselective Allyl–Alkene Coupling
Key Points
Key points are not available for this paper at this time.
Abstract
The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.