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The physiological roles of newly described PDGFRα + interstitial cells in neurotransmission within the gastrointestinal (GI) tract have predominantly come from studies on isolated cells. Here we used an inhibitor of PDGFRα, crenolanib, to examine the effects of PDGFRα + cells in enteric inhibitory neurotransmission. Crenolanib caused loss of PDGFRα + cells and neurally evoked fast inhibitory junction potentials associated with purine neurotransmission, providing evidence for the function of PDGFRα + cells within intact tissues of the GI tract.
Hwang et al. (Wed,) studied this question.