Key result
One-anastomosis gastric bypass shows no difference in complications versus sleeve gastrectomy.
Why the study?
Literature comparing one-anastomosis gastric bypass and sleeve gastrectomy regarding complications, mortality, perioperative parameters, reflux, malnutrition, and quality of life is scarce.
Does one-anastomosis gastric bypass compared to sleeve gastrectomy improve complications, perioperative status, and quality of life in patients undergoing bariatric surgery?
Meta-Analysis
Does one-anastomosis gastric bypass compared to sleeve gastrectomy improve complications, perioperative status, and quality of life in patients undergoing bariatric surgery?
Odds Ratio: 1.37 (95% CI 0.78–2.41)
OAGB and SG have similar overall complication rates, but SG is associated with higher mortality and GORD, whereas OAGB carries a higher risk of malnutrition.
Supports equivalent safety profiles for OAGB and SG; extends evidence guiding perioperative choices in bariatric surgery.
BACKGROUND: One-anastomosis gastric bypass (OAGB) and sleeve gastrectomy (SG) are safe and effective bariatric surgeries. Literature assessing the complications, mortality, operative time/minutes, hospital stay/days, gastroesophageal reflux (GORD), malnutrition, and quality of life is scarce. AIM: To compare OAGB and SG regarding the above outcomes. METHODS: We searched 4 databases from inception up to July 2025. The keywords bariatric surgery, metabolic surgery, gastric bypass, SG, complications, perioperative, quality of life, operative time, hospital stay, GORD, malnutrition, and mortality were used. Out of 1163 studies retrieved, 54 full texts were reviewed, and 31 studies were included in the meta-analysis. RESULTS: No significant differences were evident between OAGB and SG regarding complications, odds ratio (OR), 1.37, 95% confidence interval (CI): 0.78-2.41. Operative time/minutes, hospital stay/days, and quality of life were similar between the two procedures, mean differences, 2.55, 95%CI: 3.61-8.70; -0.55, 95%CI: -1.12 to 0.02; and -0.37, 95%CI: -1.18 to 0.43 respectively, in sub-analyses including super-obesity and high diabetes, no significant differences were found regarding complications rate and operative time with higher hospital stay in patients with diabetes. Mortality and GORD were higher in SG, OR, 4.70, 95%CI: 1.64-13.52, and OR, 3.23, 95%CI: 1.56-6.72, while malnutrition was more common in OAGB, OR, 0.46, 95%CI: 0.36-0.59. CONCLUSION: There were no differences between OAGB and SG regarding complications, mortality, operation time/minutes, hospital stay/days, and quality of life. Mortality and GORD were higher in SG, while malnutrition was higher in OAGB. Further well-controlled trials comparing OAGB and SG regarding long-term outcomes are needed.
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Hyder Osman Mirghani (2026) conducted a meta-analysis in Obesity requiring bariatric surgery. One-anastomosis gastric bypass (OAGB) vs. Sleeve gastrectomy (SG) was evaluated on Complications (OR 1.37, 95% CI 0.78-2.41). One-anastomosis gastric bypass showed no significant difference in complications compared to sleeve gastrectomy (OR 1.37; 95% CI 0.78-2.41).
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