Key result
Height-adjusted and 180cm BPLs associate with lower weight loss but superior comorbidity improvement vs 200cm.
Why the study?
Variations in biliopancreatic limb (BPL) length may influence outcomes in one-anastomosis gastric bypass (OAGB), but the efficacy and safety of height-adjusted BPL compared to fixed lengths remained unassessed.
Does height-adjusted or 180 cm biliopancreatic limb length improve outcomes and safety compared to 200 cm length in patients undergoing one-anastomosis gastric bypass?
Cohort (n=3,617)
Does height-adjusted or 180 cm biliopancreatic limb length improve outcomes and safety compared to 200 cm length in patients undergoing one-anastomosis gastric bypass?
p-value: p=< 0.05
While a 200 cm biliopancreatic limb length in OAGB enhances weight loss, height-adjusted and 180 cm lengths offer better comorbidity improvement and a lower risk of hypoalbuminemia.
Height-adjusted BPL may balance weight loss with lower hypoalbuminemia risk in OAGB; leaves open optimal length pending prospective trials.
is an increasingly popular surgical technique, with variations in biliopancreatic limb (BPL) length potentially influencing outcomes. This study aims to assess the efficacy and safety of height-adjusted BPL compared to fixed lengths (180 cm and 200 cm) in OAGB. This retrospective cohort study included 3,617 patients who underwent OAGB from 2011 to 2022. Patients were categorized into three groups based on BPL length: 200 cm (Group 1), 180 cm (Group 2), and height-adjusted (Group 3). Propensity score matching was used to compare total weight loss (TWL), comorbidity improvement, anemia, and hypoalbuminemia rates. Group 1 (200 cm BPL) demonstrated significantly higher TWL at most time points compared to Groups 2 and 3 (p < 0.05). However, Groups 2 and 3 showed superior improvements in comorbidities, particularly in T2DM and hypertension control. Safety analysis revealed a higher incidence of hypoalbuminemia in Group 1 at 12 months, while anemia rates were similar across groups. While a longer BPL (200 cm) may enhance weight loss, height-adjusted and 180 cm BPL lengths offer a lower incidence of hypoalbuminemia.
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Jazaeri et al. (2025) conducted a cohort in Patients undergoing one-anastomosis gastric bypass (n=3,617). Height-adjusted biliopancreatic limb (BPL) length vs. Fixed BPL lengths (180 cm and 200 cm) was evaluated on Total weight loss (TWL) (p=< 0.05). Height-adjusted and 180 cm biliopancreatic limb lengths in OAGB resulted in lower total weight loss (p<0.05) but superior comorbidity improvement and lower hypoalbuminemia rates than 200 cm lengths.
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