The recent exciting developments concerning the structure and function of the Cu A site in cytochrome c oxidase (COX) and nitrous oxide reductase are reviewed. The XRD structures of a mitochondrial and a bacterial COX have been reported in 1995. In COX, the Cu A centre is located in subunit II and is involved in electron transfer from a cytochrome c donor to the oxygen binding centre of the protein. The structural studies on the enzyme have revealed the coordination geometries of the many metal centres of COX, including the Cu A site. A combination of spectroscopic and mutagenesis studies on the Cu A centre led to the correct prediction of the structure of this unique copper centre. The construction of a Cu A site in type 1 blue copper proteins is briefly discussed.
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Dennison et al. (1996) studied this question.
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